Cellular and Genetic Mechanisms
Course Directors:
John Pintar, PhD
Frank Wilson, PhD
Mike Newlon, PhD
Ramsey Foty, PhD
Cellular and Genetic Mechanisms is a multi-departmental course
taught in the first year, fall semester, to medical and physician
assistant students. The course presents the structure and function
of the cells and tissues of the body as revealed by light and electron
microscopy. Key concepts in cellular biology form the foundation
for the students’ understanding of how cells can organize
into tissues. In addition, the students are exposed to relevant
histopathologies to emphasize the importance of normal structure.
Following an initial examination of cells, structures within the
nucleus and their role in protein synthesis are considered by analyzing
the biochemistry of DNA and RNA. Lectures on the cell cycle and
its control serve as an introduction to the genetics component of
the course. Some of the topics in genetics include an analysis of
chromosome structure, the human genome and cancer genetics. The
course concludes with an introduction to the basic tissues of the
body in anticipation of information presented in the spring semester’s
Systems Histology course.
The major goals of the course are stated below:
- Knowledge of the normal structure and function of the cells
and tissues of the body.
- Knowledge of the molecular, biochemical, and cellular mechanisms
important in maintaining the body’s homeostasis.
- Knowledge of the various causes (genetic, developmental, metabolic,
toxic, microbiologic, autoimmune, neoplastic, degenerative, and
traumatic) of maladies and the ways in which they operate on the
body (pathogenesis).
- Knowledge of the altered structure and function (pathology
and pathophysiology) of the body and its major organ systems that
are seen in various diseases and conditions.
- An understanding of the power of the scientific method in establishing
the causation of disease and efficacy of traditional and non-traditional
therapies.
- Knowledge of the most frequent clinical, laboratory, roentgenologic,
and pathologic manifestations of common maladies.
- Knowledge of the epidemiology of common maladies within a defined
population, and the systematic approaches useful in reducing the
incidence and prevalence of those maladies.
Cellular and Genetic Mechanisms Faculty
Michael C. Newlon, Ph.D., Course Director
UMDNJ-Robert Wood Johnson Medical School
Department of Molecular Genetics, Microbiology and Immunology
675 Hoes Lane, Room 732-A, Piscataway, NJ 08854
Phone: (732) 235-5448/Fax: (732) 235-5223
e-mail: mnewlon@umdnj.edu
John Pintar, Ph.D., Course Director
UMDNJ-Robert Wood Johnson Medical School
Department of Neuroscience and Cell Biology
683 Hoes Lane, SPH-359, Piscataway, NJ 08854
Phone: (732) 235-4250
e-mail: pintar@umdnj.edu
Frank J. Wilson, Ph.D., Course Director
UMDNJ-Robert Wood Johnson Medical School
Department of Neuroscience and Cell Biology
675 Hoes Lane, Room R349, Piscataway, NJ 08854
Phone: (732) 235-4071/Fax: (732) 235-4029
e-mail: fwilson@umdnj.edu
Ramsey A. Foty, Ph.D., Course Director
UMDNJ-Robert Wood Johnson Medical School
Department of Surgery
Clinical Academic Building
125 Patterson Street, Room 7319, New Brunswick, NJ 08901
Phone: (732) 235-7482
e-mail: fotyra@umdnj.edu
Janet Baxter, Course Co-Administrator
UMDNJ-Robert Wood Johnson Medical School
Department of Biochemistry
675 Hoes Lane, Room S206, Piscataway, NJ 08854
Phone: (732) 235-4311
e-mail: baxterjh@umdnj.edu
Mary Beth Sparta, Course Co-Administrator
UMDNJ-Robert Wood Johnson Medical School
Department of Neuroscience and Cell Biology
675 Hoes Lane, Room R327, Piscataway, NJ 08854
Phone: (732) 235-4580/Fax: (732) 235-3926
e-mail: spartamb@umdnj.edu
Elena Ashkinadze, M.S.
UMDNJ-Robert Wood Johnson Medical School
Department of Obstetrics and Gynecology
Division of Maternal-Fetal Medicine
125 Patterson Street, Room 2117
New Brunswick, NJ 08901
e-mail: ashkinadze@umdnj.edu
Ann Bretschneider
UMDNJ-Robert Wood Johnson Medical School
Department of Neuroscience and Cell Biology
675 Hoes Lane, Room R327, Piscataway, NJ 08854
Phone: (732) 235-4580
e-mail: histo@optonline.net
Linda Brzustowicz, M.D.
Rutgers University, Department of Genetics
Nelson Biological Laboratories – B314
604 Allison Road, Piscataway, NJ 08854-8095
Phone: (732) 445-3331 – Direct Line/Fax: (732) 445-1636
Phone: (732) 445-1027 Genetics Office
Laboratory: (732) 445-1637
e-mail: brzustowicz@biology.rutgers.edu
Kiran Chada, D. Phil.
UMDNJ-Robert Wood Johnson Medical School
Department of Biochemistry
675 Hoes Lane, Room R604, Piscataway, NJ 08854
Phone: (732) 235-4783
e-mail: chada@umdnj.edu
Cheryl Dreyfus, Ph.D.
UMDNJ-Robert Wood Johnson Medical School
Department of Neuroscience and Cell Biology
683 Hoes Lane, SPH-361, Piscataway, NJ 08854
Phone: (732) 235-5382
e-mail: dreyfus@umdnj.edu
Celine Gelinas, Ph.D.
UMDNJ-Robert Wood Johnson Medical School
Department of Biochemistry
679 Hoes Lane, CABM-132, Piscataway, NJ 08854
Phone: (732) 235-5035
e-mail: gelinas@cabm.rutgers.edu
Jean Gibney, B.A.
UMDNJ-Robert Wood Johnson Medical School
Department of Neuroscience and Cell Biology
675 Hoes Lane, Room R327, Piscataway, NJ 08854
Phone: (732) 235-4580
e-mail: gibneyjean@aol.com
Mike Hampsey, Ph.D.
UMDNJ-Robert Wood Johnson Medical School
Department of Biochemistry
683 Hoes Lane West, SPH-285, Piscataway, NJ 08854
Phone: (732) 235-5888
e-mail: hampsemi@umdnj.edu
Sarah Hitchcock-DeGregori, Ph.D.
UMDNJ-Robert Wood Johnson Medical School
Department of Neuroscience and Cell Biology
675 Hoes Lane, Room R330, Piscataway, NJ 08854
Phone: (732) 235-4528
e-mail: hitchcoc@umdnj.edu
Cynthia Israel
UMDNJ-School of Health Related Professions
675 Hoes Lane, PA Building, Piscataway, NJ 08854
Phone: (732) 235-4445
e-mail: israelcy@umdnj.edu
Marilyn Kozak, Ph.D.
UMDNJ-Robert Wood Johnson Medical School
Department of Biochemistry
663 Hoes Lane West, SRB-162, Piscataway, NJ 08854
Phone: (732) 235-5355
e-mail: kozakma@umdnj.edu
Michael Matise, Ph.D.
UMDNJ-Robert Wood Johnson Medical School
Department of Neuroscience and Cell Biology
675 Hoes Lane, Room R-325, Piscataway, NJ 08854
Phone: (732) 235-3471
e-mail: matisemp@umdnj.edu
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