the pure gold of research

The value of disease registries lies in the completeness of the collected data (Ingelfinger 2004). Controlled clinical trials have strict rules for admission, studying only a small percent of patients, and cost a lot of money to carry out. In contrast, research using existing administrative data is inexpensive in effort and money, and includes whole populations (Chambless 1997) .

The MIDAS project (as the New Jersey Myocardial Infarction surveillance System) was initially funded in 1990 by pilot grants from the State of New Jersey and the Robert Wood Johnson Foundation to use hospital billing administrative data to explore areas of interest in myocardial infarction epidemiology and the results were published in Circulation (MIDAS 1). Since then, MIDAS has been supported by internal funding from the Department of Medicine and has published 10 papers and presented over 40 abstracts (see attached publication list).

The MIDAS study group continues work in the linkage of all cardiovascular disease admissions and readmissions for subsequent events and invasive cardiology procedures (e.g. revascularization) in order to construct a longitudinal framework to characterize the changing trends and natural history of cardiovascular disease and utilization of invasive cardiology services in New Jersey .

•  Ingelfinger JR, Drazen JM. Registry research and Medical Privacy. N Engl J Med 2004;350:1452-3

•  Chambless L, Keil U, Dobson A, Mahonen M, Kuulasmaa K, Rajakangas AM, Lowel H, Tunstall-Pedoe H. Population versus clinical view of case fatality from acute coronary heart disease: results from the WHO MONICA Project 1985-1990. Multinational MONItoring of Trends and Determinants in CArdiovascular Disease. Circulation . 1997;96(11):3849-59.

Publications

•  MIDAS 1.   Kostis JB, Wilson AC, O'Dowd K, Gregory P, Chelton S, Cosgrove NM, Chirala A, Cui T. for the MIDAS Study Group.   Sex differences in the management and long term outcome of acute myocardial infarction. A statewide study.   Circulation 90(4) 1715-1730 October (1994)   

•  MIDAS 2. Abbud ZA, Shindler DM, Wilson AC, Kostis JB, for the MIDAS Study Group. Effect of diabetes mellitus on short and long term mortality of patients with acute myocardial infarction. A statewide study. Am Heart J 130:51-58 July (1995)              

•  MIDAS 3. Moreyra AE, Wilson AC, Gregory PM, Kostis JB. Coronary angioplasty during hospitalization for acute myocardial infarction is associated with higher 5-year survival.   Disease Management and Clinical Outcomes   1(5)175-189 September/October (1998)              

•  MIDAS 4. Gregory PM, Rhoads GG, Wilson AC, O'Dowd KJ, Kostis JB. Impact of availability of hospital-based invasive cardiac services on racial differences in the use of these services.   Am Heart J 138:507-517 September (1999)  Editorial comment      

•  MIDAS 5. Gregory PM, Malka ES, Kostis JB, Wilson AC, Arora JK, Rhoads GG.   Impact of geographic proximity to cardiac revascularization services on service utilization. Medical Care 38:45-57 January (2000).  Editorial Comment pp 396-399            

•  MIDAS 6. Liang Z-H, Wilson AC, Cosgrove NM , Kostis JB for MIDAS.   Long-term survival after in-hospital cardiopulmonary resuscitation and defibrillation in patients with acute myocardial infarction. Disease Management and Clinical Outcomes 1:41-49 February (2000).

•  MIDAS 7. Kostis JB, Wilson AC, Lacy CR, Cosgrove NM, Ranjan R, Lawrence-Nelson J. Time trends in the occurrence and outcome of acute myocardial infarction and coronary heart disease death between 1986 and 1996 (A New Jersey Statewide Study). American Journal of Cardiology 88:837-841 October (2001).

•  MIDAS 8. Al Falluji N, Lawrence-Nelson J, Kostis JB, Lacy CR, Rajiv R, Wilson AC. Effect of anemia on One-year Mortality in Acute Myocardial Infarction Patients. American Heart Journal   144:636-641 October (2002).

•  MIDAS 9. Freudenberger RS, Wilson AC, Lawrence-Nelson J, Hare JM, Kostis JB, for the Myocardial Infarction Data Acquisition System Study Group (MIDAS 9). Permanent Pacing is a Risk Factor for the Development of Heart Failure. Am J Cardiol 95:671-674 February (2005)

•  MIDAS 10 . Kostis WJ, Demissie K, Marcella SW, Shao Y-H, Wilson AC, Moreyra AE for the Myocardial Infarction Data Acquisition System Study Group. Weekend versus Weekday Admission and Mortality in Patients with Myocardial Infarction. N Engl J Med   356 1099-109 March (2007).

• MIDAS 11. Shao Y-H, Rhoads GG, Demissie K, Selim S, Marcella SW, Kostis WJ, Moreyra AE, Kostis JB for the Myocardial Infarction Data Acquisition System Study Group. Secular changes in acute myocardial infarction mortality and morbidity in New Jersey from 1990 through 2004. In revision process.

• MIDAS 12. David Q. Rich, Howard M. Kipen, Junfeng Zhang, Leena Kamat, Alan C. Wilson, John B. Kostis, for the Myocardial Infarction Data Acquisition System Group. Triggering of transmural infarctions, but not non-transmural infarctions, by ambient fine particles. Submission to Circulation pending Feb 2009.

LETTERS

•  Kostis JB, Wilson AC, Lacy CR. Survival trends, coronary event rates, and the MONICA project. Lancet 354:862-865 September(1999) Letter to the Editors

ABSTRACTS

1. Kostis JB, Wilson AC, Cosgrove NM , Blachman S, for MIDAS. Gender differences in the diagnosis, management and prognosis of acute myocardial infarction. A statewide database.   J Am Coll Cardiol 19(3): 20A (1992) Presented at the 41st Annual Scientific Session of the ACC in Dallas TX , April 1992.
2. Kostis JB, Wilson AC, Cosgrove NM . Relationship of day of the week to occurrence, severity, procedures and mortality of acute myocardial infarction. A statewide database.   Eur Heart J 13(suppl):278 (1992) Presented at the XIV Congress of the European Society of Cardiology in Barcelona , Spain , Sept 1992.
3. Wilson AC, Cui T, Cosgrove NM , Kostis JB.   Seasonal periodicity of acute myocardial infarction and association with birthdays and holidays.   J Am Coll Cardiol 21:436A (1993) Presented at the 42nd Annual Scientific Session of the ACC in Anaheim , CA , March 1993.
4. Kostis JB, Wilson AC, Gregory P, Cosgrove NM, Cui T, Chirala A, O'Dowd K for MIDAS. Long term mortality of acute myocardial infarction with and without cardiac catheterization in men and women. J Am Coll Cardiol 21:176A (1993) Presented at the 42nd Annual Scientific Session of the ACC in Anaheim , CA , March 1993.
5. Wilson AC, Cui T, Gregory P, Cosgrove N, Kostis JB. Hypertension as a protective factor in patients surviving acute myocardial infarction.   Am J Hypertension 6(II):88A (1993) Presented at the Am Soc of Hypertension 8th Scientific Meeting in New York City , May 1993.
6. Kostis JB, Wilson AC, Gregory P. Management and long term outcome of acute myocardial infarction in men and women. II Cuore X (Sup 4):203 (1993) Presented at the 6th Ann Meet of Medit Assoc of Cardiol and Cardiac Surgery, Corfu, Greece, Sept 1993.
7. Moreyra AE, Wilson AC, Gregory P, Kostis JB.   Lower 3-year mortality is associated with angioplasty during hospitalization for acute myocardial infarction.   Circulation 88(4): I-410 (1993) Presented at the 66th Annual Scientific Session of the AHA in Atlanta GA , November 1993.
8. Moreyra AE, Wilson AC, Gregory P, Kostis JB.   Improved 3-year survival after early angioplasty during hospitalization for acute myocardial infarction. Eur. Heart J. 15:(Abstract Supplement) 309(1994) Presented at the XVI Congress of the European Society of Cardiology in Berlin , Germany , Sept 1994.
9. Abbud ZA, Shindler DM, Wilson AC, Kostis JB, for MIDAS. Effect of diabetes on short and long term mortality of acute myocardial infarction. A statewide study. Circulation 90(4): I-501 (1994) Presented at the 67th Annual Scientific Session of the AHA in Dallas , TX . November 1994.
10. Crabbe DL, Wilson AC, Kostis JB, for MIDAS. Race and gender as factors influencing management and 3-year survival outcome after acute myocardial infarction. Circulation 90(4): I-502 (1994) Presented at the 67th Annual Scientific Session of the AHA in Dallas , TX . November 1994.
11. Moreyra AE, Wilson AC, Gregory P, Kostis JB.   Early angioplasty during hospitalization for acute myocardial infarction improves 3-year survival. J Am Coll Cardiol   Supp 231A: 755-1 (1995) Presented at the 44th Annual Scientific Session of the ACC in New Orleans , LA , March 1995.
12. Liang Z-H, Wilson AC, Kostis JB for MIDAS. Changing hospital mortality and use of invasive procedures in acute myocardial infarction.   Circulation 92: I-27(1995) .Presented at the 68th Annual Scientific Session of the AHA in Anaheim , CA. November 1995.
13. Liang Z-H, Wilson AC, Cosgrove NM , Kostis JB for MIDAS.   Long term survival after hospital CPR in acute myocardial infarction. Circulation 92:I-174(1995). Presented at the 68th Annual Scientific Session of the AHA in Anaheim , CA. November 1995.
14. Liang Z-H, Wilson AC, Kostis, AC. Variation in length of stay and readmission for patients with myocardial infarction between 1986 and 1994. J Am Coll Cardiol 29(Supp A): 348A (1997). Presented at the 46th Annual Scientific Session of the ACC in Anaheim , CA , March 1997.
15. Gregory P, Rhoads G, Wilson A, O'Dowd K, Kostis J for the MIDAS study group. Double or Nothing? A baseline study of the impact of availability of cardiac services on racial differences in cardiac service use and mortality. Abstr Book Assoc Health Serv Res. 16:154 (1997) Presented as poster at the 14th Annual Meeting of the Association for Health Services Research (ASHR) in Chicago , IL , June1997.
16. Gregory P, Rhoads G, Wilson A, Kostis J for the MIDAS study group.   Statewide monitoring for effect of health insurance coverage on use of cardiac services and mortality after acute myocardial infarction. Conference Proceedings Presented at the1997 Convention of the American Public Health Association, Indianapolis , IN ,   Nov 1997.
17. Gregory P, O'Dowd K, Rhoads G, Wilson A, Kostis J for the MIDAS study group.   The "MIDAS Touch" to record linkage of large administrative data files to study heart disease. Conference Proceedings Presented at the 1997 Convention of the American Public Health Association, Indianapolis , IN , November 1997.
18. Gregory P, Rhoads G, Wilson AC, Kostis for the MIDAS study group.   Racial differences in the use of invasive cardiac services: the impact of health insurance status.   Circulation 96(8):I-618 (1997). Presented at the 70th Annual Scientific Session of the AHA in Orlando , FL , November 1997.
19. Gregory PM, Malka ES, Kostis JB, Wilson AC, Arora JK, Rhoads GG.   Geographic proximity to invasive cardiac services as a barrier to utilization for Blacks compared to Whites.   Abstr Book Assoc Health Serv Res. 16:154 (1999) Presented at 39th Annual Conference on Cardiovascular Disease Epidemiology and Prevention, March 24-27, 1999, Orlando , FL
20. Wilson AC, Lacy CR, Cosgrove NM , Kostis JB. Increasing Frequency of Coronary Heart Disease among the Elderly in New Jersey : 1986-1996. Circulation 100(18):I-103 (1999) Presented at 72nd AHA Scientific Sessions, Atlanta , GA. , November 8, 1999.
21. Ranjan R, Lawrence-Nelson J, Wilson AC, Lacy CR, Kostis JB. Changes in Length of Hospital Stay and Mortality in Patients with Acute Myocardial Infarction. Circulation 102(18):II-851 (2000) Presented at the AHA Scientific Sessions 2000, New Orleans, LA, November 12, 2000
22. John B. Kostis, Alan C. Wilson, Janet Lawrence-Nelson, Rajiv Ranjan, Nora M. Cosgrove, Clifton R. Lacy, Pearl D'Sa.   1126-100. Increase in Mortality of Patients Discharged With the Diagnosis of Acute Myocardial Infarction Between 1986 and 1996. J Am Coll Cardiol 41(5, Supp A):366A (2003). Presented at 52nd Annual Scientific Session, Chicago , IL , March 31, 2003  
23. Alan C. Wilson, John B. Kostis, Janet Lawrence-Nelson, Nora M. Cosgrove, Pearl D'Sa, for MIDAS. Changing Sex Differences in Invasive Cardiac Procedure Rates Following Acute Myocardial Infarction. J Am Coll Cardiol 41(5, Supp A):527A (2003). Presented at 52nd Annual Scientific Session, Chicago , IL , March 31, 2003  
24. Maya E. Guglin, Alan C. Wilson, John B. Kostis, Joseph E. Parrillo, Lawrence J. Gessman. Immediate and One-Year Survival of Sudden Death Victims in Southern New Jersey .  Presented at NASPE 25th Annual Scientific Sessions, May 19-22, 2004, San Francisco , CA
25. Abel E. Moreyra, Alan C. Wilson, Y-H Shao, John B. Kostis Length of Stay (“Balloon-to-Door Time”) Following Primary Percutaneous Coronary Intervention for Acute Myocardial Infarction: A Report from the 2002-2003 New Jersey MIDAS database. Circulation 112(17):II-570 (2000) Presented at the AHA Scientific Sessions, Dallas , TX , October, 2005
26. Yu-Hsuan Shao, Alan C. Wilson, Ronald S. Freudenberger, William J. Kostis, Nora M. Cosgrove, John B. Kostis, for the MIDAS Study Group. The Changing Characteristics and In-Hospital Mortality of Acute Myocardial Infarction in New Jersey 1986-2002. J Am Coll Cardiol 47 (4, Supp 1):172A (2006). Presented at 55th Annual Scientific Session, Atlanta , GA , March 12, 2006  
27. William J. Kostis, Yu-Hsuan Shao, Alan C. Wilson, Nora M. Cosgrove, Ronald S. Freudenberger, John B. Kostis, for the MIDAS Study Group. Gender and Racial Differences in Invasive Diagnostic and Interventional Cardiac Procedures in the Management of Acute Myocardial Infarction: 15-Year Trends in a Statewide Database. J Am Coll Cardiol 47 (4, Supp 1):161A (2006). Presented at 55th Annual Scientific Session, Atlanta , GA , March 12, 2006  
28. Alan C. Wilson, Yu-Hsuan Shao, Nora M. Cosgrove, William J. Kostis, Ronald S. Freudenberger, John B. Kostis, for the MIDAS Study Group. Long-Term Mortality and Changing Cause of Death in Patients With Acute Myocardial Infarction in New Jersey 1986-1998. J Am Coll Cardiol 47 (4, Supp 1):230A (2006). Presented at 55th Annual Scientific Session, Atlanta , GA , March 14, 2006  
29. William J. Kostis, Kitaw Demissie, Stephen W. Marcella, Yu-Hsuan Shao, Alan C. Wilson, Abel E. Moreyra, Differences in Mortality between Weekend and Weekday Admission for Acute Myocardial Infarction (A 16-Year New Jersey Statewide Study) Circulation 114(18):II-860 (2006) Presented at AHA Scientific Sessions, Chicago, IL, November, 2006
30. Yu-Hsuan Shao, Alan C. Wilson, William J. Kostis, Nora M. Cosgrove, Abel E. Moreyra, John B. Kostis Recurrence of Acute Myocardial Infarction in a Statewide Database Circulation 114(18):II-879 (2006) POSTER Presented at the AHA Scientific Sessions, Chicago, IL, November, 2006 
31. Kostis JB, Shao Y-H, Wilson AC, Cosgrove NM, Kostis WJ, Moreyra AE for the MIDAS Study Group. Increase of post-discharge mortality of patients with acute myocardial infarction in New Jersey: 1986-2002. Circulation 114(18):II-599 (2006) POSTER Presented at AHA Scientific Sessions, Chicago, IL, November, 2006
32. Yu-Hsuan Shao, Alan C. Wilson, Nora M. Cosgrove, John B. Kostis Lack of Improvement in Outcomes of Black Patients after Myocardial Infarction: 17-year Trends in NJ. Circulation 115(8) February 27 (2007) Presented at 47th Annual Conference on CVD Epidemiolgy and Prevention, Orlando , FL March 2007.
33. Cosgrove NM , Kostis WJ, Shao Y-H, Wilson AC, Moreyra AE, Kostis JB for the MIDAS Study Group.Myocardial Infarction After Age Ninety: Outcomes in 10,213 Nonagenarians. J Am Coll Cardiol 49 (9, Supp A):198A (2007). Presented at 56th Annual Scientific Session, New Orleans , LA , March 25, 2007  
34. Shao Y-H, Moreyra AE, Wilson AC, Kostis WJ, Cosgrove NM,Kostis JB for the MIDAS Study Group The False Paradox Of Higher Case-Fatality of Acute Myocardial Infarction Among Young Women Compared to Men. J Am Coll Cardiol 49 (9, Supp A):233 (2007). Presented at 56th Annual Scientific Session, New Orleans , LA , March 26, 2007  
35. Abel E. Moreyra, William J. Kostis, Stephen W. Marcella, Yu-Hsuan Shao, Alan C. Wilson, Kitaw Demissie Trends In Profile And Mortality Of Patients With Acute Myocardial Infarction From 1987 To 2002: A New Jersey Statewide Study. J Am Coll Cardiol 49 (9, Supp A):291A (2007). Presented at 56th Annual Scientific Session, New Orleans , LA , March 26, 2007  
36. William J. Kostis, Yu-Hsuan Shao, Alan C Wilson, Abel E. Moreyra, John B. Kostis. Comparison in Occurrence, Clinical Profile, and Mortality of Patients with Acute Myocardial Infarction and Stroke, Alone and in Combination (A Statewide Report). Circulation 116(16):II-417 (2007) Presented at the AHA Scientific Sessions, Orlando , FL , November, 2007
37. Yu-Hsuan Shao, Alan C. Wilson, Nora M. Cosgrove, William J. Kostis, Abel E. Moreyra, John B. Kostis. Changes in Post Discharge Outcome of Acute Myocardial Infarction in a Statewide Database. Circulation 116(16):II-525 (2007) Presented at the AHA Scientific Sessions, Orlando , FL , November, 2007
38. Alan C Wilson, Yu-Hsuan Shao, Nora M. Cosgrove, John S. Pantazopolous, Abel E. Moreyra, John B. Kostis. Changing Age Distribution of First Ever Acute Myocardial Infarction Among Men and Women in New Jersey Hospitals. Circulation 116(16):II-832 (2007) Presented at the AHA Scientific Sessions, Orlando , FL , November, 2007
39. William J. Kostis, Yu-Hsuan Shao, Abel E. Moreyra, Alan C. Wilson, John B. Kostis, For the Myocardial Infarction Data Acquisition System (MIDAS) Study Group. Decreasing Coronary Heart Disease Mortality Over Two Decades: Prevention or Postponement? (A New Jersey Statewide Study). J Am Coll Cardiol 51 (10, Supp A):A216 (2008). Presented at 57th Annual Scientific Session, Chicago , IL , March 29, 2008.
40. Yu-Hsuan Shao, William J. Kostis, Abel E. Moreyra, Alan C. Wilson, Nora M. Cosgrove, John B. Kostis, For the Myocardial Infarction Data Acquisition System (MIDAS) Study Group. Divergent Trends in Stroke and Myocardial Infarction Incidence and Case-Fatality (A New Jersey Statewide Study). J Am Coll Cardiol 51 (10, Supp):A309-310 (2008). Presented at 57th Annual Scientific Session, Chicago , IL , March 29, 2008.   
41. Tudor D. Vagaonescu, Abel E. Moreyra, Alan C. Wilson, Nora Cosgrove, John B. Kostis. Patients with Acute Myocardial Infarction Receiving Drug Eluting Stents Have Better Survival Compared to Patients Receiving Bare Metal Stents. A New Jersey Statewide Database Study. Circulation 118(12) September 16, 2008: e469 Presented at World Congress of Cardiology in Buenos Aires, Argentina, May18, 2008 .
42. Yingzi Deng; William J Kostis; Yu-Hsuan Shao, Alan C Wilson, Nora M Cosgrove, Abel E. Moreyra, John B Kostis. Comparisons Of Rates, Characteristics and Outcomes of Hospitalized Stroke. Eleven Year Trends In A State-wide Database. Circulation 117(21) May 27, e467, 2008    Presented at the 9th Scientific Forum on Quality of Care and Outcomes Research in Cardiovascular Disease and Stroke, Baltimore , Maryland , April 30 - May 2, 2008.
43. Kostis WJ, Yingzi Deng, Abel E. Moreyra, Yu-Hsuan Shao, Alan C Wilson, Nora M. cosgrove, John B Kostis. Impact of diagnostic and interventional procedures on outcomes of hospitalized stroke. Changes between 1994 and 2004 in a statewide database. Circulation 117(21) May 27, e467, 2008  Presented at the 9th Scientific Forum on Quality of Care and Outcomes Research in Cardiovascular Disease and Stroke, Baltimore , Maryland , April 30 - May 2, 2008
44. Yingzi Deng, William J Kostis; Yu-Hsuan Shao, Alan C Wilson, Nora M Cosgrove, Abel E. Moreyra, John B Kostis. Intracranial hemorrhage as complication of thrombolysis and its impact on outcomes of stroke patients in a state-wide registry. Presented at the 41st Annual Society for Epidemiologic Research Meeting, held June 24-27, 2008 in Chicago , Illinois
45. J.B. Kostis, Y.-H. Shao, A.E. Moreyra, G.G. Rhoads. Increasing long-term mortality of acute myocardial infarction patients . Presented at the ESC Congress, September 2008 , Munich , Germany. European Heart Journal ( 2008 ) 29 (Abstract Supplement ), 70
46. T. Vagaonescu, A.E. Moreyra, A.C. Wilson, N. Cosgrove, J.B. Kostis. Drug eluting stents are associated with better survival and outcomes than bare metal stents after percutaneous coronary intervention for acute myocardial patients: a state wide registry analysis. Presented at the ESC Congress, September 2008 , Munich , Germany. European Heart Journal ( 2008 ) 29 (Abstract Supplement), 577
47. Yingzi Deng, William J Kostis, Alan Wilson, Nora Cosgrove, Yu-Hsuan Shao, Abel Moreyra, John B Kostis. The Impact of Atrial Fibrillation on the outcomes of patients suffering a second Myocardial Infarction: Circulation 2008;118:S_818., Poster presentation, November 11, 2008, AHA Scientific Sessions, New Orleans, LA.
48. Abel E. Moreyra, Alan C. Wilson, Yingzi Deng, Nora M. Cosgrove, John B. Kostis, For the Myocardial Infarction Data Acquisition System (MIDAS) Study Group. Lack of Change in Occurrence Rate and Long-Term Outcome of Patients with Post-Infarction Ventricular Septal Rupture: A 21-year Study. J Am Coll Cardiol 5X (XX, Supp):AXXX (2009). Accepted for poster Presentation at 58th Annual Scientific Session, Orlando, FL, Monday March 30, 2009. 9:30 to 10:30am
49. Tudor D Vagaonescu, Alan C Wilson, Abel E Moreyra. Transfusions after Percutaneous Coronary Intervention for Acute Myocardial Infarction Patients are Associated with Increased Long Term Mortality: A Statewide Registry Study. Accepted for poster presentation at the i2 summit held in conjunction with the American College of Cardiology 58th Annual Scientific Session, March 28-March 31, 2009, in Orlando , Florida , USA .
50. Syed A. Hussain, Alan C. Wilson, Abel E. Moreyra. Improved Outcomes Post Coronary Revascularization with Drug Eluting Stents Compared to Coronary Artery Bypass Surgery in Patients with End Stage Renal Disease on Hemodialysis. Accepted for presentation at the i2 summit held in conjunction with the American College of Cardiology 58th Annual Scientific Session, March 28-March 31, 2009, in Orlando , Florida , USA .
51. David Q. Rich, Howard M. Kipen, Junfeng Zhang, Leena Kamat, Alan C. Wilson, John B. Kostis. Triggering of myocardial infarction by ambient fine particle concentration, differences in response by MI severity and presence of chronic obstructive pulmonary disease. Accepted for presentation at the AHA Council on Epidemiology and Prevention Meeting (in March).