Annual Report

PUBLICATIONS BY FULL-TIME FACULTY

T.J. Thomas, Ph.D.

Thomas, T., Gallo, M.A., and Thomas, T. J. (2004) Estrogen receptors as targets for drug development for breast cancer, osteoporosis and cardiovascular diseases. Current Cancer Drug Targets 4, 483-499.

Balabhadrapathruni, S., Santhakumaran, L.M., Thomas, T.J., Shirahata, A., Gallo, M.A., and Thomas, T. (2005) Bis(ethyl)norspermine potentiates the apoptotic activity of the pure antiestrogen ICI 182780 in breast cancer cells. Oncol. Rep . 13, 101-108.

Lewis, J. S., Thomas, T. J., Pestell, R. G ., Albanese, C., Gallo, M. A., and Thomas T. (2005) Differential effects of 16a-hydroxyestrone and 2-methoxyestradiol on cyclin D1 involving the transcription factor ATF-2 in MCF-7 breast cancer cells. J. Mol. Endocrinol . 34, 91-105.

Vijayanathan, V., Lya ll, J., Thomas, T., Shirahata, A., and Thomas, T. J. (2005) Ionic, structural, and temperature effects on DNA nanoparticles formed by natural and synthetic polyamines. Biomacromolecules 6, 1097-1103.

Venkiteswaran, S., Vijayanathan, V., Shirahata, A., Tho mas, T., and Thomas, T. J. (2005) Antisense recognition of the HER-2 mRNA: effects of phosphorothioate substitution and polyamines on DNA.RNA, RNA.RNA, and DNA.DNA duplex stability. Biochemistry 44, 303-312.

Lewis, J. S., Vijayanathan, V., Thomas, T. J., Pestell, R. G., Albanese, C., Gallo, M.A., and Thomas, T. (2005) Activation of cyclin D1 by estradiol and spermine in MCF-7 breast cancer cells: A mechanism involving the p38 MAP kinase and phosphorylation of ATF-2. Oncology Res . 15, 113-128.

Santhakum aran, L.M., Chen, A., Pillai, C.K.S., Thomas, T., He, H., and Thomas, T. J. (2005) Nanotechnology in Nonviral Gene Delivery, In: Nanofabrication Towards Biomedical Applications. pp: 253-287. C.S.S.R. Kumar, J. Hormes, C. Leuschner (Eds.) WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. Book Chapter.

Abstracts

Beck, A., Vijayanathan, V., Thomas, T., and Thomas, T. J. (2005) Environmental factors on triplex DNA stabilization. Proc. Amer. Assoc. Cancer Res. 46, 90.

Nair, S.K., Thomas, T. J., Greenfiel d, N., Chen, A., He, H., and Thomas, T. (2005) Thermal unfolding of estrogen receptors a and b. Proc. Amer. Assoc. Cancer Res. 46, 1140.

Vijayanathan, V., Thomas, T. J., Gallo, M.A., and Thomas, T. (2005) 2-Methoxyestradiol inhibits the non-genomic action of estradiol in MCF-7 breast cancer cells. Proc. Amer. Assoc. Cancer Res. 46, 1358.

Vivian Hsu, M.D.

Korn JH., Mayes JD., Matucci Cerinic M., Rainisio J., Pope et al (HsuVM): Digal ulcers in systemic sclerosis-prevention by treatment with bosentan, an oral endothelin receptor antagonist Arthritis Rheum 5 0(12):3985-3993, 2004

Denton DP., Merkel PS., Furst DE., Khanna D., Emery P., Hsu VM, et al: Safety and tolerability of recombinant anti-TGF B1 antibody therapy in diffuse cutaneous scleroderma: a multicenter, randomized, placebo-controlled Phase I/II trial of CAT-192. Arthritis Rheum (in press).

Hsu VM, Moreyra A., Shinnar M., Shindler D., Wilson A., Wilson JE, Desai A., Seibold JR: Assessment of pulmonary hypertension in systemic sclerosis (SSc): a comparison of Doppler echocardiography, cardiac MRI, and right heart catheterization. Arthritis Rheum (in press)

Abstracts

Denton C., Merkel P., Clements P., Khanna D., Emery P., Hsu VM, et al: Anti-TGFB1 immunotherapy for diffuse cutaneous systemic sclerosis-a multicenter, randomized, placebo-controlled Phase I/II trial of CAT192. Arthritis Rheum 50(9Supp):S691: Abstract#1851, 2004.

Merkel PA, Silliman N., Denton C., Clements PJ, Emery P., Furst DE, Hsu VM et al: Validity and feasibility of durometer measurements of scleroderma skin disease in a multicenter treatment trial. Arthritis Rheum 50 (9Supp)L S424; Abstract # 1044, 2004.

Hsu Vm, Moreyra A., Shinnar M., Shindler D., Wilson A., Wilson JE, Desai A., Seibold JR: Assessment of pulmonary hypertension in systemic sclerosis (SSc): a comparison of Doppler echocardiography, cardiac MRI and right heart catheterization. Arthritis Rheum 50 (9Supp): S424; Abstract #1059, 2004.

Seibold JR, Black C., Denton C., Hsu VM, et al: Six Minute Walk Test (6MWT) in interstitial lung disease in systemic sclerosis (SSc): Preliminary results from the BUILD2 trial. Proc 8 th International Workshop Scleroderma Research, Cambridge, UK, August 2004 Scleroderma Care & Research 2(2)20, 2005.

Afton Hassett, Psy.D

Hassett AL, Radvanski DC, Moorthy LN, Sigal LH, Antibiotic treatment in medically unexplained symptoms ascribed to Lyme disease. Arthritis Rheum 2004; 50(9):S489-905.

Hassett AL, Radvanski DC, Buyske S, Sigal LH. Maladaptive schemas in chronic Lyme disease. Arthritis Rheum 2004; 50(9):S464-5.

Radvanski DC, Vaschillo EG, Vaschillo B, Hassatt AL, Lehrer PM. A 10-session trial of Heart Rate Varibility biofeedback in fibromyalgia. Arthritis Rheum 2004; 50(9):S79.

Hassett AL, Radvanski DC, Vaschillo EG, Vaschillo B, Lehrer PM. A trial of Heart Rate Variability biofeedback in fibromyalgia. The proceedings from the Sixth World Congress on Myofascial Pain and Fibromyalgia, Munich, Germany. J Musculoskel Pain 2004; 12(9):S9.

Naomi Schlesinger, M.D.

Schlesinger N. Management of Acute and Chronic Gouty Arthritis: Present State-of –the-Art. Drugs; 2004;64(21):2399-416.

Schlesinger N, Lardizabal A., Jayanti Rao, Jyoti Rao, McDonald R. Tuberculosis of the spine: Experience in an inner city hospital. J Clin. Rheumatol 2005;11:17-20.

Schlesinger N, Schlesinger M. Seasonality of rheumatic disorders. Discovery Medicine 2005;5:64-69.

Schlesinger N, Schlesinger M, Seshan SV. Seasonal Variations of Lupus Nephritis. J Rheumatol 2005; 32:1053-7.