Annual Report

Full Length Papers in Peer Reviewed Journals

Subbaramaiah K, Yoshimatsu K, Scherl E, Das KM, Glazier KD, Golijanin D, Soslow RA, Tanabe T, Naraba H, Dannenberg AJ. Microsomal prostaglandin E synthase-1 overexpressed in inflammatory bowel disease. Evidence for involvement of the transcription factor Egr-1. J Bio Chem. 279:12647-58, 2004.

Shen EH, Das KM. Current therapeutic recommendations: infliximab for ulcerative colitis. J Clin Gastro., 38:741-45, 2004.

Glazier KD, Palance AL, Griffel LH, Das KM. The ten-year single-center experience with 6-mercaptopurine in the treatment of inflammatory bowel disease. J. Clin Gastroenterol., 39:21-26, 2005.

Ebert EC, Mehta V, Das KM. Activation antigens on colonic T cells in inflammatory bowel disease. Clin Exp Med., 140:157-65, 2005.

Kovvali G, Das KM. Hypothesis - Molecular mimicry may contribute to pathogenesis of ulcerative colitis. FEBS Letters, 579:2261-66, 2005.

Sun JH, Das KM. Therapeutic recommendations - Low dose oral methotrexate for maintaining Crohn's disease. Remission: where we stand. J Clin Gastro., Accepted for publication.

Sun JH, Das KK, Amenta PS, Yokota K, Watari J, Sato T, Kohgo Y, Das KM. Preferential expression of cyclooxygenase-2 in colonic-phenotype of gastric intestinal metaplasia: Association with helicobacter pylori and gastric carcinoma. J Clin Gastro., Accepted for publication.

Ebert EC. IL-12 up-regulates perforin- and Fas-mediated lymphokine activated killer activity by intestinal intraepithelial lymphocytes. Clin Exp Immunol., 38:259-65, 2004.

Meresse B, Chen Z, Ciszewski C, Tretiakova M, Bhagat G, Krausz TN, Raulet DH, Lanier LL, Groh V, Spies T, Ebert EC, Green PH, Jabri B. Coordinated induction by IL-15 of a TCR-independent, NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease. Immunity 21:357-66, 2004.

Ebert EC. IL-15 converts human intestinal intraepithelial lymphocytes to CD94 + producers of IFN? and IL-10, the latter promoting fas ligand-mediated cytotoxicity. Immunology 115:118-26, 2005.

Chen YK, Raijman I, Ben-Menachem T, Starpoli AA, Liu J, Pazwash H, Weiland S, Shahrier M, Fortajada E, Saltzman JR, Carr-Locke DL. Long-term outcomes of endoluminal gastroplication: A U.S. multicenter trial. GIE 61:659-67, 2005.

Abstracts Presented at National and International Meetings

Biancone L, Palmieri GP, Bozzi RM, Colantoni M, Cretella M, Geremia A, Petruzziello C, Das KM, Pallone F. Ileal lesions in ulcerative colitis: relationship with the development of colonic metaplasia after ileo-rectal anastomosis.

Liu J, Geng X, Souza R, Das KM. Amplification of a colon epithelial protein in Barrett cells following chronic exposure to acid environment.

Ebert EC, Geng X, Panja A, Liu J, Das KM. Sera from active ulcerative colitis (UC) contain IgG antibodies against human tropomyosin isoform 5 (hTM5) that kill normal colonic epithelial cells.

Sun JH, Liu J, Geng X, Lin J, Das KM. Cellular immune response against a novel tropomyosin isoform, TC22, in ulcerative colitis: an association with early development of dysplasia.

Das KK, Liu J, Kovvali G, Minacapelli C, Das KM. The effect of sulfasalazine and its metabolites, 5-aminosalicylate (mesalamine) and sulfpyradine, on the expression of tropomyosin TM isoforms 5 and a novel TM, TC22, highly associated with ulcerative colitis and colon cancer.

Pickett OE, Trivedi C, Das KM. Colonic metaplasia and COX-2 expression in the esophagogastric junction (EGJ) of patients with symptomatic gastroesophageal reflux disease (GERD) in the absence of Barrett's epithelium.

Pickett OE, Amenta PS, Das KM. Proton pump inhibitors may not influence bioimarker expression in patients with established Barrett's epithelium (BE).

Peyton A, Sonnenberg E, Wilson A, Das K. Effect of dose of 5-ASA on inducing remission in ulcerative colitis.

Yasuda A, Watari J, Das KM, Tanabe H, Ishikawa C, Inaba Y, Moriichi K, Okamoto A, Fujiya M, Ayabe T, Ashida T, Kohgo Y. Effects of Helicobacter pylori on microsatellite instability and cellular phenotype in gastric intestinal metaplasia in patients with chronic gastritis and gastric cancer: a prospective 1-year follow-up study.

Yantiss RK, Das KM, Farraye FA, Odze RD. Alterations in Das-1 and CG-3 expression in colonic mucosal biopsies help distinguish ulcerative colitis from Crohn's disease.

Ebert EC. Alefacept reduces constitutive CD2-mediated interferon (IFN)-gamma production by lamina propria lymphocytes in Crohn's disease.

Ebert EC, Jabri B. TCR-independent IL-15-induced interferon-gamma production by lamina propria lymphocytes is transiently upregulated by IL-12.